Pdf podoplanin is a novel myoepithelial cell marker in. The expression of endothelial cell marker pecam1 was tested to discriminate lymphatic endothelium from salivary gland cells, and myoepithelial cells were identified by an antibody for pcadherin. Neural control of salivary myoepithelial cells the physiological. The salivary glands include paired major glands pa. Podoplanin is a novel myoepithelial cell marker in pleomorphic adenoma and other. The latter is a relatively new smooth muscle antibody that has been shown to be a specific and fairly sensitive marker of myoepithelial cells in salivary gland neoplasms. Pathology outlines epithelial myoepithelial carcinoma. Characterization of the myoepithelial cells in the major salivary. Microscopic examination shows that myoepithelial cells are thin and spindleshaped and situated between the basement membrane and epithelial cells. Myoepithelial carcinoma malignant myoepithelioma of the parotid. Salivary gland tumors an update october 2019 ian pereira, md. In salivary glands, the myoepithelial cells that surround the intercalated ducts are spindled in contrast to the large stellate ones that envelop the acini. Minor salivary glands also have mixed serous and mucous acini in.
Myoepithelial cells are stellateshaped and also known as basket cells. Cytology of myoepithelial carcinoma of the salivary gland. Acinic cell ca basaloid adenoca myoepithelial ca adenoid cystic ca pleomorphic adenoma epithelial myoepithelial ca warthins oncocytic ca mucoepidermoid ca salivary duct ca. Proliferative activity of myoepithelial cells in normal salivary glands. They are present in the sweat glands, mammary glands, lacrimal glands and in salivary glands. In normal salivary gland, podoplanin was specifically localized in.
Myoepithelial cells are normal constituent of the salivary acini and smaller ducts, and are found between the epithelial cells and the basement membrane. Twentythree neoplasms arising in major and minor salivary glands have been found to be composed of two types of myoepithelial cells the plasmacytoid and spindle cell form. K5k14positive cells contribute to salivary gland like breast tumors with myoepithelial differentiation. Myoepithelial cells are believed to be of ectodermal origin.
Myoepithelial cells in pathology pubmed central pmc. Myoepithelial cells present a complex immunophenotype, with the expression of. Myoepithelial cells, which are found many places in the body, are contractile which means they can function to forcibly express or squeezeout the contents of a gland. They are interposed between the secretory cells and the basal lamina. The abluminal cells are identifiable as myoepithelial cells in the distal portion of the gland acinus and intercalated duct and basal cells in the proximal portion of. Expression of podoplanin in the mouse salivary glands. Immunohistochemical expression of vimentin, calponin. Myoepithelial cells mec of the salivary glands in health. Twenty three salivary gland specimens acc, 10 nsg were studied using double immunohistochemical labeling for. Morphologically, the parotid gland has the characteristics of a mixed. Immunohistochemical staining of myoepithelial cells is variably positive for vimentin, smooth muscle. Pathophysiology of myoepithelial cells in salivary glands. It is concluded that the myoepithelial cells of the salivaryglands are supplied with a.